IV Administer at least 15 min for 2 g & at least 30 min for 4 g.
Adult & adolescent >12 yr weighing >40 kg w/ CrCl >80 mL/min Max individual dose: Not to exceed 8 g.
Osteomyelitis, nosocomial lower resp tract infection 12-24 g in 2-3 divided doses.
Complicated UTI 12-16 g in 2-3 divided doses.
Bacterial meningitis 16-24 g in 3-4 divided doses. High-dose regimen in 3 divided doses is used in severe infections expected or known to be caused by less susceptible bacteria.
Childn 1-12 yr & infant weighing 10-40 kg 200-400 mg/kg in 3-4 divided doses;
infant 1-12 mth weighing up to 10 kg 200-300 mg/kg in 3 divided doses;
neonate 40-44 wk 200 mg/kg in 3 divided doses;
premature neonate <40 wk 100 mg/kg in 2 divided doses.
Renal impairment Increased loading dose up to 100%; not to exceed 8 g.
CrCl 40 mL/min 70% of appropriate dose in normal renal function in 2-3 divided doses;
30 mL/min 60% of appropriate dose in normal renal function in 2-3 divided doses;
20 mL/min 40% of appropriate dose in normal renal function in 2-3 divided doses;
10 mL/min 20% of appropriate dose in normal renal function in 1-2 divided doses.
Patient undergoing chronic intermittent dialysis every 48 hr 2 g at the end of each dialysis session.
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